SUMMARY
A series of cyclic and acyclic aminophosphonates was synthesized for agrochemical application. The
compounds differed in the substituents at the carbon, nitrogen and phosphorus atoms. Their potential
biological activity was checked by studying their hemolytic potency, since hemolysis of erythrocytes
by various compounds was found earlier to be a good indicator of their pesticidal efficiency. A
series of hemolytic experiments permitted us to check the pesticidal efficiency of
aminophosphonates and to determine what structural features of aminophosphonates are responsible
for it.
Parallelly, we studied the hemolytic efficiency of binary mixtures of the aminophosphonates with
the well-known herbicide 2,4-dichlorophenoxyacetic acid (2,4-D...) The aim was to check if potential
biological efficiencies could be enhanced in comparison with those found for individual components
due to interactions between aminophosphonates and 2,4-D. An analysis of the effects binary
mixtures was carried out by constructing graphs for both components of binary mixtures that give
the same hemolysis (the isobole method).
KEY WORDS
aminophosphonates; biological activity; erythrocytes; binary mixtures
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