SUMMARY
The present study was performed to assess and compare the therapeutic efficacy of various
oximes (methoxime, BI-6, HI-6) combined with benactyzine (BNZ) in cyclosarin (GF-agent)-
poisoned mice and to evaluate the influence of pretreatment with PANPAL (pyridostigmine,
benactyzine and trihexyphenidyl) on the effect of antidotal treatment in mice poisoned with
the GF-agent. In the first part of our experiment, methoxime, BI-6 or HI-6 in combination
with benactyzine were used for the treatment of GF-poisoned mice. In the second part of the
experiment the animals were pretreated with PANPAL 60 min before the GF-agent challenge
and then the oxime therapy was applied in the same time scheme as before. All the
therapeutic regimens showed a protective ratio higher than 2 and significantly increased the
LD50 of GF-agent. The most efficacious oxime in decreasing of GF-agent toxicity was HI-6.
PANPAL increased the protective ratios of all therapeutic regimens in comparison with
administration of the oxime and BNZ alone. From the results obtained, the combination of
pretreatment with PANPAL and following therapy with BNZ and HI-6 seems to be the most
efficacious therapeutic regimen for treatment of GF-agent-poisoned mice.
KEY WORDS
GF-agent; cyclosarin; benactyzine; pyridostigmine; PANPAL; oxime
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