SUMMARY
Fluoride has long been known to influence the activity of various enzymes in vitro. Latterly it has
been demonstrated that many effects primarily attributed to fluoride are caused by a synergistic
action of fluoride plus aluminum. Fluorinated chemicals are of growing importance, with
applications in medicine. Fluorine substitution has profound effects on the properties of organic
compounds. The very high electronegativity of fluorine can modify electron distribution in the
molecule, affecting its absorption, distribution and metabolism. Fluorine-containing drugs are used in
medicine as anesthetics, antibiotics, anti-cancer and anti-inflammatory agents,
psychopharmaceuticals, and in many other applications. The potential contribution of fluorinating
pharmaceuticals to human fluoride exposure is discussed.
KEY WORDS
fluoride; aluminofluoride complexes; fluorine-containing drugs; health effects
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