SUMMARY
Owing to the threat of organophosphate exposures, not only to pesticides but also to nerve agents, it is
very important to know the whole process of organophosphates-inhibited acetylcholinesterase (AChE, EC
3.1.1.7) reactivation. Although current antidotes against organophosphorus intoxications consist also of
prophylactics, AChE reactivators are still needed especially in the case of intoxications with high doses of
organophosphates, for which prophylactic treatment is not effective. For this reason, new AChE
reactivators are still being developed. Our work summarizes accurately the whole reactivation process,
and offers some help for scientists who are interested in the area of AChE reactivation.
KEY WORDS
acetylcholinesterase; reactivation; nerve agents; kinetics; thermodynamics; oximes
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