SUMMARY
The present study was undertaken to investigate the antihyperammonemic efficacy of the leaf extract of
Pongamia pinnata, an indigenous plant used in Ayurvedic Medicine in India (PPEt), on blood ammonia,
plasma urea, uric acid, non-protein nitrogen and serum creatinine in control and ammonium chloride
induced hyperammonemic rats. The levels of blood ammonia, circulatory urea, uric acid, non-protein
nitrogen and creatinine increased significantly in rats treated with ammonium chloride and decreased
significantly in rats treated with PPEt and ammonium chloride. There were no significant changes in the
body weights of the experimental animals when compared to controls. The antihyperammonemic effect of
PPEt could be attributed to (1) its nephroprotective effect by means of detoxifying excess urea and
creatinine, (2) its free radical scavenging property, and (3) its antioxidant property. The exact mechanism
of antihyperammonemic effect PPEt has still to be investigated and isolation of the active constituents is
required.
KEY WORDS
ammonium chloride; Pongamia pinnata; urea; uric acid; creatinine; non-protein nitrogen
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