SUMMARY
Arterial hypertension is a polygenic disease and about 50 candidate genes have been analysed. We
followed the size of the heart sections and the endothelial function in juvenile hypertensives according to
the polymorphisms in the genes for angiotensin converting enzyme (I/D), endothelin 1 (Lys198/Asn) and
endothelin 1 converting enzyme (Thr341/Ile).
We observed 44 juvenile hypertensives and 94 controls of the same age. An echocardiographic
examination was carried out during standard examinations. The endothelial function was analysed with
the use of ultrasound with high acuity after revoking a reactive hyperaemia. The genotypisations were
performed using the polymerase chain reaction and restriction analysis. Statistical analyses were carried
out using the BMDP statistical software.
There were no differences between controls and hypertensives in alleles frequency. The
hypertensives differed from the control group in the endothelial function (statistically significant). The
hypertensives homozygotes D/D and the heterozygotes Lys198/Asn had a larger left ventricle
(statistically significant); the hypertensives with the Thr341/Ile had a larger left ventricle septum
(statistically significant) and back wall of the left ventricle (statistically significant) than the controls with
the same genotype.
We concluded that the genes for ACE, endothelin 1 and endothelin 1 converting enzyme have an
influence on the size of the heart sections and on the endothelial function of the juvenile hypertensives.
KEY WORDS
juvenile hypertension; polymorphisms; angiotensin converting enzyme; endothelin-1; endothelin-1 converting enzyme
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CITED
Seremak-Mrozikiewicz A, Barlik M, Perlik M, Kurzawinska G, Drews K. Genetic variability of endothelin-1 system in gestational hypertension and preeclampsia.
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