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Journal of APPLIED BIOMEDICINE
ISSN 1214-0287 (on-line)
ISSN 1214-021X (printed)

Volume 4 (2006), No 2, p 87-94




GOSA, a Simulated Annealing-Based Program for global optimization of nonlinear problems, also reveals transyears

Jerzy Czaplicki, Germaine Cornelissen, Franz Halberg

Address: Jerzy Czaplicki, Universite Paul Sabatier, Institut de Pharmacologie et de Biologie Structurale CNRS, 205, route de Narbonne, 31077 Toulouse France
cgeorge@ipbs.fr

Received 12th January 2006.
Revised 14th March 2006.
Published online 10th April 2006.

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SUMMARY
Transyears in biology have been documented thus far by the extended cosinor approach, including linearnonlinear rhythmometry. We here confirm the existence of transyears by simulated annealing, a method originally developed for a much broader use, but described and introduced herein for validating its application to time series. The method is illustrated both on an artificial test case with known components and on biological data. We provide a table comparing results by the two methods and trust that the procedure will serve the budding sciences of chronobiology (the study of mechanisms underlying biological time structure), chronomics (the mapping of time structures in and around us), and chronobioethics, using the foregoing disciplines to add to concern for illnesses of individuals also a budding focus on diseases of societies, like crime, and of nations and civilizations, like war.

KEY WORDS
simulated annealing; linear-nonlinear rhythmometry; transyears; cosinor


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