SUMMARY
Lymphoedema, a pathological accumulation of extracellular water (ECW), is a severe post-operative
complication. Multifrequency bioimpedance analysis (MFBIA) is a method for the detection of changes
in ECW. Our aim is to establish the methodology of MFBIA and to apply it on to group of patients
undergoing breast cancer surgery.
We measured a control group of 60 women, another group of 5 women with pronounced
lymphoedema and a group of 36 patients undergoing breast cancer surgery during a 9-month period after
surgery using MFBIA and circumferential measurements for recording volume changes in the upper limb.
Different linear extrapolations from 1, 5, 50, 100, 200 kHz were determined to find resistance at 0 Hz for
each patient; ratios of R0 were evaluated for non-dominant/dominant and non-operated/operated limbs.
Pearson's correlation coefficient was used to compare the correlation between the results and patient
characteristics.
Extrapolation using 5, 50, 100 kHz had the lowest standard deviation. Within the patients with
pronounced lymphoedema, bigger differences were found by MFBIA as compared with circumference
measurements. A stronger correlation between limb volumes calculated from circumference
measurements with weight and BMI as compared with MFBIA was found. Lymphoedema was found in
14 women in the tested group. The best association between patients' subjective symptoms was with the
MFBIA measurement.
KEY WORDS
lymphoedema; post-operative complication; multifrequency bioelectrical impedance analysis; breast cancer
REFERENCES
Armer J: The problem of post-breast cancer
lymphedema: impact and measurement issues.
Cancer Invest 23:76-83, 2005.
Box RC, Reul-Hirche HM, Bullock-Saxton JE
et al.: Physiotherapy after breast cancer
surgery: results of a randomized controlled
study to minimize lymphoedema. Breast
Cancer Res Treat 75:51-64, 2002.
Cornish BH, Thomas BJ, Ward LC: Improved
prediction of extracellular and total body water
using impedance loci generated by multiple
frequency bioelectrical impedance analysis.
Phys Med Biol 38:337-346, 1993.
Cornish BH, Bunce IH, Ward LC et al.:
Bioelectrical impedance for monitoring the
efficacy of lymphoedema treatment
programmes. Breast Cancer Res Treat
38:169-176, 1996.
Cornish BH, Ward LC: Data analysis in
multiple-frequency bioelectrical impedance
analysis. Physiol Meas 19:275-283, 1998.
Cornish BH, Chapman C, Hirst C et al.: Early
diagnosis of lymphoedema using multiple
frequency bioimpedance. Lymphology 34:2-11, 2001.
Cornish BH, Thomas BJ, Ward LC et al.:
A new technique for the quantification of
peripheral edema with application in both
unilateral and bilateral cases. Angiology
53:41-47, 2002.
Dittmar M, Reber H: New equations for
estimating body cell mass from bioimpedance
parallel models in healthy older Germans. Am
J Physiol Endocrinol Metab 281:1005-1014, 2001.
Gerber LH: A review of measures of
lymphedema. Cancer 83:2803-2804, 1998.
Hayes S, Cornish B, Newman B: Comparison of
methods to diagnose lymphoedema among
breast cancer survivors: 6-month follow-up.
Breast Cancer Res Treat 89:221-226, 2005.
Kissin MW, Querci della Rovere G, Easton D et
al.: Risk of lymphedoema following the
treatment of breast cancer. Br J Surg 73:580-584, 1986.
Mikes DM, Cha BA, Dym CL et al.:
Bioelectrical impedance analysis revisited.
Lymphology 32:157-165, 1999.
Ward LC, Byrne K, Rutter K: Reliability of
multiple frequency bioelectrical impedance
analysis: An inter-machine comparison. Am J
Hum Biol 9:63-72, 1997.
|
CITED
Halaska M, Strnad P, Chod, J, Mala I, Novackova M, Stankusova H, Kolarik D, Feldmar P, Rob L: Detection of postoperative lymphoedema in patients with breast
cancer [Detekce pooperacniho lymfedemu u pacientek s karcinomem prsu] Ceska Gynekologie 72:298-304, 2007.
|
