SUMMARY
Healthy cells strictly regulate gene transcription to control crucial cellular regulatory pathways. Members
of the Jun protein family, c-Jun, JunB, and JunD are key subunits of the transcription factor AP-1 that
controls transcription from various gene promoters. The genes targeted by Jun affect essential life
processes, such as cell cycle progression, differentiation or programmed cell death. Therefore, the loss of
proper Jun function is often associated with cancer. This review summarizes recent advances in
understanding of function of the Jun proteins in healthy and cancer cells.
KEY WORDS
AP-1; Jun; cancer; apoptosis; cell cycle; differentiation
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CITED
Pazos E, Jimenez-Balsa A, Mascarenas JL, Vazquez ME. Sensing coiled-coil proteins through conformational modulation of energy transfer processes - selective
detection of the oncogenic transcription factor c-Jun. Chem Sci. 2: 1984-1987, 2011.
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