SUMMARY
Down syndrome (DS) is often accompanied by autoimmune diseases. Among those, autoimmune thyroid disease,
type 1 diabetes and celiac disease are the most common. The major cause of enhanced vulnerability of DS patients to
a variety of autoimmune diseases is impaired immune response, with multiple abnormalities in all components of the immune system,
especially in cell-mediated immunity. This could explain a significantly higher frequency of autoimmune disorders in DS compared
to the general population. The diagnosis of autoimmune diseases accompanying DS could be complicated by masking effects
of the underlying features of the syndrome such as failure to thrive, short stature and delayed puberty. However, screening
for immunological signs of coexistent autoimmunity such as tissue-specific antibodies and monitoring insulin secretion, glucose levels,
thyroid function and other metabolic parameters should help in early diagnosis of coexistent autoimmunity in DS patiens.
KEY WORDS
autoimmune thyroid disease; celiac disease; coexistence; Down syndrome; type 1 diabetes
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CITED
Nabavi SM, Hamzehloo A, Sabet Z. Down syndrome presenting with multiple sclerosis, thyroid dysfunction, and diabetes mellitus Multiple autoimmune disorders in a genetic disorder. Neurosci. 16: 375-377, 2011.
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