SUMMARY
Phenylhydrazine (PHZ) and its derivatives were first given a medical application at the end of the 19th
century but with very little benefit. However, this compound seems to be very useful in models studying
mechanisms of haemolytic anaemia. Phenylhydrazine induces a reactive oxygen species formation,
peroxidation of lipids and oxidative degradation of spectrin in the membrane skeleton. PHZ-induced
haemolytic injury seems to be derived from oxidative alternations to red blood cell proteins. This
compound can modulate immune reactions.
KEY WORDS
reactive oxygen species; membrane proteins; spectrin; haemolytic anaemia; mutagenity
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