SUMMARY
In the present investigation, we studied the effect of aqueous green tea extract (GTE), alcoholic
turmeric extract (ATE), and water-soluble Chitosan (WSC), individually/or in mixture, on the
testicular tissue content of total cholesterol (TC), triglycerides (TG), phospholipids (PL), and
thiobarbituric acid reactive substance (TBARS), in addition to nitric oxide (NO) in obese rats.
The testicular weight of the obese rats was increased more significantly than control; TC, TG, PL,
TBARS and NO were significantly higher in the obese group. GTE reduced testicular weight and
significantly reduced other estimated parameter. ATE significantly increased testicular weight, with
apparent peritesticular vascular congestion. It significantly decreased all other studied parameters.
WSC significantly increased testicular weight, with significant reduction of all other parameters. The
mixture of the three drugs non-significantly decreased testicular weight, and significantly decreased
other parameters, except NO, which was significantly more elevated than the obese control. We
concluded that obesity induced a significant increase in testicular weight, in addition to TC, TG, PL,
TBARS and NO, in comparison to the normal control subjects. An efficient protection against obesityinduced
changes was achieved by each individual drug, while the mixture of GTE, ATE and WSC
showed less protective potential than each individual drug.We here recommend the use of GTE, ATE
in treating obesity-related testicular dysfunction and suggest that attention should be paid to the
possible effect of WSC on the bioavailability of other concomitantly-used drugs and suggest a
pertinent clinical benefit of both GTE and ATE.
KEY WORDS
obesity; green tea; turmeric; Chitosan; testes; rats
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