SUMMARY
The present study investigated the effect of the aqueous extract of Helicteres isora L (Sterculiaceae) bark on
oxidative stress in the heart of rats during diabetes. The aqueous extract of Helicteres isora bark
(100 mg, 200 mg/kg body weight (b.w.)) was screened for its antioxidant effect in streptozotocin (STZ)
induced diabetic rats. An appreciable decrease in peroxidation products, thiobarbituric acid reactive substances
(TBARS), conjugated dienes (CD), and hydroperoxides (HP) was observed in the heart tissues of Helicteres isora
(HI) treated diabetic rats. The decreased activities of key antioxidant enzymes such as superoxide dismutase (SOD),
catalase (CAT), glutathione peroxidase (GPx), glutathione-S-tranferase (GST) and glutathione (GSH) in diabetic rats
were brought back to near normal range upon HI treatment. Tolbutamide was used as the standard reference drug.
These results suggest that HI possesses promising antioxidative activity in STZ diabetic rats.
KEY WORDS
Helicteres isora; Sterculiaceae; diabetes; lipid peroxidation; antioxidant enzymes
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