Obsah souboru
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<b><font color="#3366FF"><font size=+4>Journal of APPLIED BIOMEDICINE</font></font></b><br>
ISSN 1214-0287 (on-line)<br>
ISSN 1214-021X (printed)
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Volume 6 (2008), No 4, p 187-193
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Effect of chronic administration of quinine on the myocardium of mice
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David Adesanya Ofusori, Sunday Joel Josiah, Abiodun Oladele Ayoka, Emmanuel Oluwole Omotoso, Samson Ayodeji Odukoya
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Address: D. A. Ofusori,
Department of Anatomy and Cell Biology,
Faculty of Basic Medical Sciences,
Obafemi Awolowo University, Ile-Ife,
Osun State, Nigeria
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<a href="mailto:davidofus234@yahoo.com">davidofus234@yahoo.com </a>
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Received 3rd July 2008.<br>
Revised 30th October 2008.<br>
Published online 12th December 2008.<br>
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<a href="http://www.zsf.jcu.cz/jab/6_4/ofusori.pdf">Full text article (pdf)</a><br>
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<a href="http://www.zsf.jcu.cz/jab/6_4/ofusori.xml">Abstract in xml format</a><br><br>
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<a name="summary"><b>SUMMARY</b></a><br>
This study was designed to evaluate the effect of chronic administration of quinine on the myocardium of Swiss albino mice. 20 or 30mg quinine/kg b.w. were administered for 30 consecutive days, while the control mice received equal amounts of normal saline. The mice were sacrificed 24 hours after the last administration. Some of the hearts were excised and processed for light microscopic study while some were assayed for malondialdehyde (MDA) and catalase activities. The histological findings indicated that the treated sections of the heart were at variance with the control. The myocardium in the control section presents well organized myofibrils with long cylindrical mononucleated cells in contrast to a dose dependent distorted arrangement of myofibrils and scanty cellular components observed in the treated sections. There was a statistically significant decrement in the weight difference and relative percentage weight of the heart in a dose dependent manner just as the activities of MDA and catalase significantly increased in the treated groups. These findings indicate that chronic administration of quinine may have some deleterious effects on the heart of mice and by extension may affect its function.
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<a name="keywords"><b>KEYWORDS</b></a><br>
quinine; heart; myocardium; histology; chronic administration; malaria<br>
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<a name="references"><b>REFERENCES</b></a><br>
Acworth IN, McCabe DR and Maber T: The analysis of free radicals, their reaction products and antioxidants. In Baskin SI, Salem H (eds.): Oxidants, Antioxidants and Free Radicals. Chapter 2, Taylor and Francis, Washington, D.C., 1997.
<br><br>
Aksenes A, Njaa L: Determination of catalase activity in fish. Comp. Biochem. Physiol. 69:893-896, 1981.
<br><br>
Anderson JK: Oxidative stress in neurodegeneration: cause or consequence? Nature Rev. Neurosci. 5:518-525, 2004.
<br><br>
Barennes H, Mahaman S, Munjakazi JM, Khenine A: Efficacy and pharmacokinetics of a new intrarectal quinine formulation in children with Plasmodium falciparum malaria. Brit. J. Clin. Pharmacol.:389, 1996.
<br><br>
Barennes H: Safety and efficacy of rectal compared with intramuscular quinine for the early treatment of moderately severe malaria in children: randomised clinical trial. Brit. Med. J. 332:1055�57, 2006.
<br><br>
Coyle JT, Puttfarcken P (1993): Oxidative stress, glutamate and neurodegenerative disorders. Sci. 262: 689-695, 1993.
<br><br>
Durdi Q, Timur R: Catalase (antioxidant enzyme) activity in streptozotocin-induced diabetic rats. Int.J. Diabetes and Metabolism,15:22-24, 2007.
<br><br>
Farber JL, Chein KR, Mittnacht S: The pathogenesis of irreversible cell injury in ischemia. Am. J. Pathol., 102:271-281, 1981.
<br><br>
Gonall AG, Bardawill CJ, David MM: Determination of total protein. J. Biol. Chem. 177:751-760, 1949.
<br><br>
Guyton AC, Hall JC: Textbook of Medical Physiology 10th Edn., W. B. Saunders Company. Philadelphia. Pennysylvania, pp. 96-97, 2000.
<br><br>
Heath JW, Young B, Burkitt HG: Circulatory system. Wheater�s functional histology 3rd ed Pg 140-145, 1999.
<br><br>
Johnson CE: Effects of fluid imbalances: Neurosciences in Medicine: P. Michael conn JB Lippincott Company; Pg. 187-189, 1995.
<br><br>
Joy D, Feng X, Mu J, Furuya T, Chotivanich K, Krettli AU, Ho M, Wang A, White NJ, Suh E, Beerli P, Su X Z: Early origin and recent expansion of Plasmodium falciparum. Sc.300:318-321, 2003.
<br><br>
Kaufman T, R�veda E: The quest for quinine: those who won the battles and those who won the war. Angew Chem. Int. Ed. Engl. 44:854-85, 2005.
<br><br>
Krotoski W, Collins W, Bray R, Garnham PCC, Cogswell FB, Gwadz RW, Killick-Kendrick R, Wolf R, Sinden R, Koontz LC, Stanfill PS: Demonstration of hypnozoites in sporozoite-transmitted Plasmodium vivax infection. Am. J. Trop. Med. Hyg. 31:1291-1293, 1982.
<br><br>
Manonmani G, Anbarasi K, Balakrishna K, Veluchamy G, Shyamala Devi CS: Effect of Terminalia arjuna on the antioxidant defense systemin alloxan induced diabetes in rats. Biomed. 22:52�61, 2002.
<br><br>
National Institute of Health Guide for the Care and Use of laboratory Animals: DHEW Publication (NIH), revised, Office of Science and Health Reports, DRR/NIH, Bethesda, USA, 1985.
<br><br>
Ofusori DA, Oluwayinka OP, Adelakun AE, Keji ST, Oluyemi KA, Adesanya O A, Ajeigbe KO, Ayoka AO: Evaluation of the effect of ethanolic extract of Croton zambesicus on the testes of Swiss albino mice. African J. Biotechnol. 6: 2434-2438, 2007.
<br><br>
Pieper GM, Jordan M, Dondlinger LA, Adams MB, Roza AM: Peroxidative stress in diabetic blood vessels. Revers a l by pancreatic islet transplantation. Diabetes 44:884-889, 1995.
<br><br>
Sachs J, Malaney P: The economic and social burden of malaria". Nature 415:680-685, 2002.
<br><br>
Snow RW, Guerra CA, Noor AM, Myint HY, Hay SI: The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature 434:214-7, 2005.
<br><br>
Tatsuki R, Satoh K, Yamamoto A, Hoshi K, Ichihara K: Lipid Peroxidation in the Pancreas and Other Organs in
Streptozotocin Diabetic Rats. Jap. J. Pharmacol 75:267-273, 1997.
<br><br>
Trager W, Jensen JB: Human malaria parasites in continuous culture. Sci.193:673�675, 1976.
<br><br>
Trampuz A, Jereb M, Muzlovic I, Prabhu R: Clinical review: Severe malaria. Crit Care 7:315-23, 2003.
<br><br>
Waters CM, Wakinshaw G, Moser B, Mitchell IJ: Death of Neurons in the neonatal rodent globus pallidus occurs as a mechanism of apoptosis. Neurosci. 63:881-894, 1994.
<br><br>
Wohaieb SA, Godin DV: Alterations in free radical tissue defense mechanisms in streptozotocin induced diabetes in rat: effects of insulin treatment. Diabetes 36:169�173, 1987.
<br><br>
Woodward R, Doering W: The Total Synthesis of Quinine. J. Am. Chem. Soc. 66:849, 1944.
<br><br>
Wyllie AH: Glucocorticoid-induced thymocyte apoptosis is associated and endogenous endonuclease activation. Nature, London. 284:555-556, 1980.
<br><br>
Yoshikawa T, Naho Y, Kishi A, Tomil Kaneko T, Inuma S, Ichikawa H, Yasudha M, Takahshi S, Kondo M: Role of active oxygen, lipid peroxidation and antioxidants in the pathogenesis gastric mucosal injury induced by indomethacin in rats. Gut 34:732�737, 1993.<br><br>
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