SUMMARY
This study was designed to evaluate the effect of chronic administration of quinine on the myocardium of Swiss albino mice. 20 or 30mg quinine/kg b.w. were
administered for 30 consecutive days, while the control mice received equal amounts of normal saline. The mice were sacrificed 24 hours after the last
administration. Some of the hearts were excised and processed for light microscopic study while some were assayed for malondialdehyde (MDA) and catalase
activities. The histological findings indicated that the treated sections of the heart were at variance with the control. The myocardium in the control section
presents well organized myofibrils with long cylindrical mononucleated cells in contrast to a dose dependent distorted arrangement of myofibrils and scanty
cellular components observed in the treated sections. There was a statistically significant decrement in the weight difference and relative percentage weight
of the heart in a dose dependent manner just as the activities of MDA and catalase significantly increased in the treated groups.These findings indicate that
chronic administration of quinine may have some deleterious effects on the heart of mice and by extension may affect its function.
KEY WORDS
quinine; heart; myocardium; histology; chronic administration; malaria
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