SUMMARY
Standard haematological procedures in preclinical subchronic and chronic toxicity studies are carried out on dogs, rats and other mammals. In vitro clonic assays CFU-GM, BFU-E, CFU-E, CFU-Mgkr and pluripotent stem cells are used in screening candidate compounds to predict acute cytopenias, but they are not able to reveal the risk of suppression which can develop after repeated administration. No in silico studies have yet been published in haematotoxicology. More recent haematotoxicological in vivo models represent invertebrates: they can be used in both ecotoxicology and in the screening of myelotoxicity.
KEY WORDS
myelotoxicity; alternative testing; in vitro; in silico; invetebrate
REFERENCES
Auffret M, Duchemin M, Rousseau S, Boutet I, Tanguy A, Moraga D, Marhic A: Monitoring of immunotoxic responses in oysters reared in areas contamined by the "Erika" oil spill. Aquat Living Resour 17:297-302, 2004.
[CrossRef]
Berger J: Haematological preclinical recording of adverse drug reactions - current status, problems, and needs. Part II. Diagnostic aspects. Folia Haematol 114:16-41, 1987.
Berger J: Preclinical testing on insects predicts human haematotoxic potentials. Lab Anim 43:328-332, 2009a.
[CrossRef]
[PubMed]
Berger J: New haemolytic potential assay on an alternative insect model. Basic Clin Pharmacol Toxicol 105:315-318, 2009b.
[CrossRef]
Berger J, Walczysko S, Pavkova J, Gutzeit HO: Effects of genistein on insect haemocytes. J Appl Biomed 1:161-168, 2003.
[JAB]
Binelli A, Riva C, Cogni D, Provini A: Genotoxic effects of p,p´-DDT (1,1,1trichloro-2,2-bis-[chlorophenyl]ethane) and its metabolites in Zebra mussel (D. polymorpha) by SCGE assay and micronucleus test. Environ Mol Mutagen 49:406-415, 2008.
[CrossRef]
[PubMed]
Bouchard N, Pelletier E, Fournier M: Effects of butyltin compounds on phagocytic activity of hemocytes from three marine bivalves. Environ Toxicol Chem 18:519-522, 1999.
[CrossRef]
Cammarata M, Parisi MG, Benenati G, Arizza V, Cillari T, Piazzese D, Gianguzza A, Vazzana M, Vizzini A, Parrinello N: In vitro effects of methylmercury on ascidian (Styela plicata) immunocyte responses. Appl Organomet Chem 21:1022-1028, 2007.
[CrossRef]
Carvalho Pinto-Silva C, Creppy EE, Matias WG: Micronucleus test in mussels Perna perna fed with the toxic diniflagelate Prorocentrum lima. Arch Toxicol 79:422-426, 2005.
[CrossRef]
[PubMed]
Choudhuri S: Looking back to the future: From the development of the gene concept to toxicogenomics. Toxicol Mech Methods 19:263-277, 2009.
[CrossRef]
[PubMed]
Cima F, Bragadin M, Ballarin L: Toxic effects of new antifouling compounds on tunicate haemocytes. I. Sea-Nine 211TM and chlorothalonil. Aquat Toxicol 86:299-312, 2008.
[CrossRef]
[PubMed]
Cummings A, Kavlock K: A systems biology approach to developmental toxicology. Reprod Toxicol 19:281-290, 2005.
[CrossRef]
[PubMed]
De Guise S, Goedken M, Morsey B, Maratea J, Sidor I, Perkins C: Development of new methods to ossess invertebrate immunology and immunotoxicology in aquaculture: Oysters and lobsters as examples. Int J Environ Pollut 33:365-380, 2008.
[CrossRef]
Dopp E, Barker CM, Schiffman D, Reinisch CL: Detection of micronuclei in hemocytes of Mya arenaria association with leukemia and induction with an akylating agent. Aquat Toxicol 34:31-45, 1996.
[CrossRef]
Flatt T, Schmidt PS: Integrating evolutionary and molecular genetics of aging. Biochim Biophys Acta 1790:951-962, 2009.
[PubMed]
Gagne F, Auclair J, Turcotte P, Fournier M, Gagnon C, Sauve S, Blaise C: Ecotoxicity of CdTe quantum dots to freshwater mussels: Impact on immune system, oxidative stress and genotoxicity. Aquat Toxicol 86:333-340, 2008.
[CrossRef]
[PubMed]
Galloway TS, Depledge MH: Immunotoxicity in invertebrates: Measurement and ecotoxicological relevance. Ecotoxicology 10:5-23, 2001.
[CrossRef]
[PubMed]
Ghielmini M, Bosshard G, Pampallona S, Genini D, Bernier J, Sessa C: Differential toxicity of anticancer drugs on late (GM-CFC) and early (LTC-IC) hemopoetic progenitors in vitro. Cell Biol Toxicol 15:395-404, 1999.
[CrossRef]
[PubMed]
Guengerich FP, MacDonald JS: Applying mechanisms of chemical toxicity to predict drug safety. Chem Res Toxicol 20:344-369, 2007.
[CrossRef]
[PubMed]
Knight A: Animal experiments scrutinised: Systematic reviews demonstrate poor human clinical and toxicological utility. ALTEX 24:320-325, 2007.
[PubMed]
Knight A: Non-animal methodologies within biomedical research and toxicity testing. ALTEX 25:213-231, 2008.
[PubMed]
Lavine MD, Strand MR: Insect hemocytes and their role in immunity. Insect Biochem Mol Biol 32:1295-1309, 2002.
[CrossRef]
Lu B: Recent advances in using Drosophila to model neurodegenerative diseases. Apoptosis 14:1008-1020, 2009.
[CrossRef]
[PubMed]
Masubuchi N: Risk assessment of human myelotoxicity of anticancer drugs: A predictive model and the in vitro colony forming unit granulocyte/macrophage (CFU-GM) assay. Pharmazie 61:135-139, 2006.
[PubMed]
Menin A, Ballarin L, Bragadin M, Cima F: Immunotoxicity in ascidians: Antifouling compounds alternative to organotins - II. The case of Diuron and TCMS pyridine. J Environ Sci Health B 43:644-654, 2008.
[CrossRef]
[PubMed]
Muster W, Breidenbach A, Fischer H, Kirchner S, Miller L, Pahler A: Computational toxicology in drug development. Drug Discov Today 13:303-310, 2008.
[CrossRef]
[PubMed]
Nigsch F, Macaluso NJM, Mitchell JBO, Zmuidinavicius D: Computational toxicology: An overview of the sources of data and of modelling methods. Expert Opin Drug Metab Toxicol 5:1-14, 2009.
[CrossRef]
Oweson C, Hernroth B: A comparative study on the influence of manganese on the bactericidal response of marine invertebrates. Fish Shellfish Immunol 27:500-507, 2009.
[CrossRef]
Oweson C, Skold H, Pinsino A, Matranga V, Hernroth B: Manganese effects on haemopoietic cells and circulating coelomocytes of Asterias rubens (Linnaeus). Aquat Toxicol 89:75-81, 2008.
[CrossRef]
[PubMed]
Park BS, Lee SE: Proteomics in insecticide toxicology. Moll Cell Toxicol 3:11-18, 2007.
Pessina A, Malerba I, Gribaldo L: Hematotoxicty testing by cell clonogenic assay in drug development and preclinical trials. Current Pharm Des 11:1055-1065, 2005.
[CrossRef]
[PubMed]
Russo J, Lefeuvre-Orfila L, Lagadic L: Hemocyte-specific response to the peroxidizing herbicide fomesafen in the pond snail Lymnaea stagnalis (Gastropoda, Pulmonata). Environ Pollut 146:420-427, 2007.
[CrossRef]
[PubMed]
Sessa C, Zucchetti M, Ghielmini M, Bauer J, D´Incalci M, de Jong J, Naegele H, Rossi S, Pacciarini MA, Domenigoni L, Cavalli F: Phase I clinical and pharmacological study of oral methoxymorpholinyl doxorubicin (PNU 152243). Cancer Chemother Pharmacol 44:403-410, 1999.
[CrossRef]
[PubMed]
Spokony RF, Restifo LL: Broad complex isoforms have unique distributions during central nervous system metamorphosis in Drosophila melanogaster. J Comp Neurol 517:15-36, 2009.
[CrossRef]
[PubMed]
Stegmaier K: Genomic approaches to small molecule discovery. Leukemia 23:1226-1235, 2009.
[CrossRef]
[PubMed]
Sung H-H, Kao W-Y, Su Y-J: Effects and toxicity of phthalate esters to hemocytes of giant freshwater prawn, Macrobrachium rosenbergii. Aquat Toxicol 64:25-37, 2003.
[CrossRef]
Szczerbina T, Banach Z, Tylko G, Pyza E: Toxic effects of acrylamide on survival, development and haemocytes of Musca domestica. Food Chem Toxicol 46:2316-2319, 2008.
[CrossRef]
[PubMed]
Vaccari T, Bilder D: At the crossroads of polarity, proliferation and apoptosis: The use of Drosophila to unravel the multifaceted role of endocytosis in tumor suppression. Mol Oncol 3:354-365, 2009.
[CrossRef]
[PubMed]
Valerio LG, Jr.: In silico toxicology for the pharmaceutical science. Toxicol Appl Pharmacol 241:356-370, 2009.
[CrossRef]
[PubMed]
Verhofstad N, Linschooten JO, van Benthem J, Dubrova YE, van Steeg H, van Schooten FJ, Godschalk RL: New methods for assessing male germ line mutations in humans and genetic risks in their offspring. Mutagenesis 23:241-247, 2008.
[CrossRef]
[PubMed]
Yang Y, Lu B: Mitochondrial morphogenesis, distribution, and Parkinson disease: Insights From PINK1. J Neuropathol Exper Neurol 68:953-963, 2009.
[CrossRef]
[PubMed]
Yildiz HY, Benli ACK: Nitrite toxicity to crayfish, Astacus leptodactylus, the effects of sublethal nitrite exposure on hemolymph nitrite, total hemocyte counts, and hemolymph glucose. Ecotoxicol Environ Saf 59:370-375, 2004.
[CrossRef]
[PubMed]
Zhou D, Visk DW, Haddad GG: Drosophila, a golden bug, for the dissection of the genetic basis of tolerance and susceptibility to hypoxia. Pediatr Res 66:239-247, 2009.
[CrossRef]
[PubMed]
|
CITED
Inagaki Y, Matsumoto Y, Kataoka K, Matsuhashi N, Sekimizu K. Evaluation of drug-induced tissue injury by measuring alanine aminotransferase (ALT) activity in silkworm hemolymph. BMC Pharmacol Toxicol. 13: Art No 13, 2012.
Finaurini S, Basilico N, Corbett Y, D'Alessandro S, Parapini S, Olliaro P, Haynes RK, Taramelli D. Dihydroartemisinin inhibits the human erythroid cell differentiation by altering the cell cycle. Toxicol. 300: 57-66, 2012.
Berger J, Jurcova M. Phagocytosis of insect haemocytes as a new alternative model. J Appl Biomed. 10: 35-40, 2012.
Desai K, Brott D, Hu X, Christianson A. A systems biology approach for detecting toxicity-related hotspots inside protein interaction networks. J Bioinform Comput Biol. 5: 647-662, 2011.
Berger J. The age of biomedicine: current trends in traditional subjects. J Appl Biomed. 9: 57-61, 2011.
|
