Obsah souboru
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<PublisherName>University of South Bohemia, Ceske Budejovice and Versita, Warsaw</PublisherName>
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<Journal>
<JournalInfo JournalType="Journals">
<JournalPrintISSN>1214-021X</JournalPrintISSN>
<JournalElectronicISSN>1214-0287</JournalElectronicISSN>
<JournalTitle>Journal of Applied Biomedicine</JournalTitle>
<JournalCode>JAB</JournalCode>
<JournalID>121649</JournalID>
<JournalURL>http://versita.metapress.com/link.asp?target=journal&id=121649</JournalURL>
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<Volume>
<VolumeInfo>
<VolumeNumber>8</VolumeNumber>
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<Issue>
<IssueInfo IssueType="Regular">
<IssueNumberBegin>2</IssueNumberBegin>
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<IssueSequence>000008000220100601</IssueSequence>
<IssuePublicationDate>
<CoverDate Year="2010" Month="6" Day="1"/>
<CoverDisplay>Number 2 / June 2010</CoverDisplay>
</IssuePublicationDate>
<IssueID>LR323T458627</IssueID>
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<Article ArticleType="Original">
<ArticleInfo Free="No" ESM="No">
<ArticleDOI>10.2478/v10136-009-0012-x</ArticleDOI>
<ArticlePII>1566851055133173</ArticlePII>
<ArticleSequenceNumber>5</ArticleSequenceNumber>
<ArticleTitle Language="En">The incidence of β-defensin-1, 2, 3 in human healthy and chronically inflamed nasal and tonsillar mucosa</ArticleTitle>
<ArticleFirstPage>81</ArticleFirstPage>
<ArticleLastPage>86</ArticleLastPage>
<ArticleHistory>
<RegistrationDate>20100524</RegistrationDate>
<ReceivedDate>20100524</ReceivedDate>
<Accepted>20100524</Accepted>
<OnlineDate>20100524</OnlineDate>
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<FullTextFileName>1566851055133173.pdf</FullTextFileName>
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<Composite>2</Composite>
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<ArticleHeader>
<AuthorGroup>
<Author AffiliationID="A1">
<GivenName>Hana</GivenName>
<Initials/>
<FamilyName>Pácová</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Author AffiliationID="A2">
<GivenName>Jaromír</GivenName>
<Initials/>
<FamilyName>Astl</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Author AffiliationID="A1">
<GivenName>Jindřich</GivenName>
<Initials/>
<FamilyName>Martínek</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Affiliation AFFID="A1">
<OrgDivision/>
<OrgName>Institute of Histology and Embryology, First Faculty of Medicine, Charles University, Prague, Czech Republic</OrgName>
<OrgAddress/>
</Affiliation>
<Affiliation AFFID="A2">
<OrgDivision/>
<OrgName>Dpt. of Otorhinolaryngology and Head and Neck Surgery, First Faculty of Medicine and Teaching Hospital Motol, Prague, Czech Republic</OrgName>
<OrgAddress/>
</Affiliation>
</AuthorGroup>
<Abstract Language="En"><p>The nasal and tonsillar mucosa are exposed to massive incursions of pathological microorganisms. One of the mechanisms known to prevent an invasion of pathogens is an endogenous synthesis of antimicrobial peptides, which include human β-defensin-1, 2, 3 (HBD-1, 2, 3).</p><p>The aim of this study was to demonstrate the occurrence of HBD-1, 2 and 3 in the human nasal mucosa and palatine tonsils in healthy tissues and during chronic inflammation (nasal polyposis with and without the colonization of <i>Staphylococcus aureus</i> and chronic tonsillitis) and to evaluate their incidence under varying conditions.</p><p>Another target was to compare the occurrence of human β-defensins in these two different entities; that is, in the nasal mucosa and in the palatine tonsil.</p><p>It was assumed that the incidence of HBD-1, 2, 3 was lower in tonsils than in nasal mucosa; however, inflamed samples of tonsils and nasal mucosa showed no difference in the production of HBD-1, 2, 3. The presence of all three subfamilies of HBD was significantly lower in nasal polyps with <i>S. aureus</i> positive than in the negative control.</p></Abstract>
<KeywordGroup Language="En">
<Keyword>β-defensins</Keyword>
</KeywordGroup>
<KeywordGroup Language="En">
<Keyword>nasal mucosa</Keyword>
</KeywordGroup>
<KeywordGroup Language="En">
<Keyword>palatine tonsil</Keyword>
</KeywordGroup>
<KeywordGroup Language="En">
<Keyword>chronic inflammation</Keyword>
</KeywordGroup>
<biblist>
<bib-other>
<bibtext seqNum="1"> Ball SL, Siou GP, Wilson JA, Howard A, Hirst BH, Hall J:. Expression and immunolocalisation of antimicrobial peptides within human palatine tonsils. <i>J Laryngol Otol</i> 121:973-978, 2007.</bibtext>
</bib-other>
<bib-other>
<bibtext seqNum="2"> Claeys S, de Belder T, Holtappels G, Gevaert P, Verhasselt B, van Cauwenberge P, Bachert C:. Human β-defensins and toll-like receptors in the upper airway. <i>Allergy</i> 58:748-753, 2003.</bibtext>
</bib-other>
<bib-other>
<bibtext seqNum="3"> Cole AM, Tahk S, Oren A, Yoshioka D, Kim YH, Park A, Ganz T:. Determinants of <i>Staphylococcus aureus</i> nasal carriage. <i>Clin Diagn Lab Immunol</i> 8:1064-1069, 2001.</bibtext>
</bib-other>
<bib-other>
<bibtext seqNum="4"> Dunsche A, Acil Y, Siebert R, Harder J, Schröder JM, Jepsen S:. Expression profile of human defensins and antimicrobial proteins in oral tissues. <i>J Oral Pathol Med</i> 30:154-158, 2001.</bibtext>
</bib-other>
<bib-other>
<bibtext seqNum="5"> Harder J, Bartels J, Christophers E, Schroeder JM:. A peptide antibiotic from human skin. <i>Nature</i> 387:861, 1997.</bibtext>
</bib-other>
<bib-other>
<bibtext seqNum="6"> Klüver E, Adermann K, Schulz A:. Synthesis and structure-activity relationship of β-defensins, multi-functional peptides of the immune system. <i>J Pept Sci</i> 12:243-257, 2006.</bibtext>
</bib-other>
<bib-other>
<bibtext seqNum="7"> Lee SH, Kim JE, Lim HH, Lee HM, Choi JO:. Antimicrobial defensin peptides of the human nasal mucosa. <i>Ann Otol Rhinol Laryngol</i> 111:135-141, 2002.</bibtext>
</bib-other>
<bib-other>
<bibtext seqNum="8"> Po-Hsu Ch, Sheen-Yie F:. Expression of human β-defensin 2 in human nasal mucosa. <i>Eur Arch Otorhinolaryngol</i> 216:238-241, 2004.</bibtext>
</bib-other>
<bib-other>
<bibtext seqNum="9"> Quinn GA, Cole AM:. Suppression of innate immunity by nasal carriage strain of <i>Staphylococcus aureus</i> increases its colonization on nasal epithelium. <i>Immunology</i> 122:80-89, 2007.</bibtext>
</bib-other>
<bib-other>
<bibtext seqNum="10"> Schibli DJ, Hunter HN, Aeyev V, Starner TD, Wiencek JM, Mccray PB:. The solution structures of human β-defensin 3 lead to better understanding of the potent bactericidal activity of HBD-3 against <i>Staphylococcus aureus. J Biol Chem</i> 277:8279-8289, 2002.</bibtext>
</bib-other>
<bib-other>
<bibtext seqNum="11"> Weise JB, Meyer JE, Helmer H, Wittrock H, Maune S:. A newly discovered function of palatine tonsils in immune defence: the expression of defensins. <i>Otolaryngol Pol</i> 56:409-413, 2002.</bibtext>
</bib-other>
</biblist>
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</Article>
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