Obsah souboru
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<PublisherName>University of South Bohemia, Ceske Budejovice and Versita, Warsaw</PublisherName>
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<JournalPrintISSN>1214-021X</JournalPrintISSN>
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<JournalTitle>Journal of Applied Biomedicine</JournalTitle>
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<CoverDate Year="2010" Month="9" Day="1"/>
<CoverDisplay>Number 3 / September 2010</CoverDisplay>
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<IssueID>W7U4305X5R35</IssueID>
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<Article ArticleType="Original">
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<ArticleDOI>10.2478/v10136-009-0015-7</ArticleDOI>
<ArticlePII>C46675411451K853</ArticlePII>
<ArticleSequenceNumber>1</ArticleSequenceNumber>
<ArticleTitle Language="En">Cell cycle and Alzheimer's disease: studies in non-neuronal cells</ArticleTitle>
<ArticleFirstPage>121</ArticleFirstPage>
<ArticleLastPage>130</ArticleLastPage>
<ArticleHistory>
<RegistrationDate>20100708</RegistrationDate>
<ReceivedDate>20100708</ReceivedDate>
<Accepted>20100708</Accepted>
<OnlineDate>20100708</OnlineDate>
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<ArticleHeader>
<AuthorGroup>
<Author AffiliationID="A1">
<GivenName>Natividad</GivenName>
<Initials/>
<FamilyName>de las Cuevas</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Author AffiliationID="A1">
<GivenName>Úrsula</GivenName>
<Initials/>
<FamilyName>Muñoz</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Author AffiliationID="A1">
<GivenName>Fernando</GivenName>
<Initials/>
<FamilyName>Bartolomé</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Author AffiliationID="A1">
<GivenName>Noemí</GivenName>
<Initials/>
<FamilyName>Esteras</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Author AffiliationID="A1">
<GivenName>Carolina</GivenName>
<Initials/>
<FamilyName>Alquezar</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Author AffiliationID="A1 A2">
<GivenName>Ángeles</GivenName>
<Initials/>
<FamilyName>Martín-Requero</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Affiliation AFFID="A1">
<OrgDivision/>
<OrgName>Department of Cellular and Molecular Medicine, Centro de Investigaciones Biológicas (CSIC)</OrgName>
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<Affiliation AFFID="A2">
<OrgDivision/>
<OrgName>Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain</OrgName>
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<Abstract Language="En">The most common cause of dementia in the elderly is Alzheimer disease (AD). In Europe, AD is a leading cause of death. The prevalence of this disease in developed countries is increasing because of very significant shifts in life expectancy and demographic parameters. AD is characterized by progressive cognitive impairment, resulting from dysfunction and degeneration of neurons in the limbic and cortical regions of the brain. Two prominent abnormalities in the affected brain regions are extracellular deposits of β-amyloid, and intracellular aggregates of tau protein in neurofibrillary tangles. The role of these features in AD pathogenesis and progression is not yet completely elucidated. Research over the last decade has revealed that the activation of cell cycle machinery in postmitotic neurons is one of the earliest events in neuronal degeneration in AD. Here we summarize evidence to support the hypothesis that cell cycle alterations occur in cells other than neurons in AD sufferers. Immortalized lymphocytes from AD patients have show an enhanced rate of proliferation associated with G1/S regulatory failure induced by alterations in the cyclin/CDK/pRb/E2F pathway. In addition, these cells have a higher resistance to serum deprivation-induced apoptosis. These neoplastic-like features, cell cycle dysfunction and impaired apoptosis can be considered systemic manifestations of AD disease.</Abstract>
<KeywordGroup Language="En">
<Keyword>Alzheimer's disease</Keyword>
</KeywordGroup>
<KeywordGroup Language="En">
<Keyword>lymphocytes</Keyword>
</KeywordGroup>
<KeywordGroup Language="En">
<Keyword>cell cycle</Keyword>
</KeywordGroup>
<KeywordGroup Language="En">
<Keyword>cell survival</Keyword>
</KeywordGroup>
<KeywordGroup Language="En">
<Keyword>p27</Keyword>
</KeywordGroup>
<KeywordGroup Language="En">
<Keyword>p21</Keyword>
</KeywordGroup>
<KeywordGroup Language="En">
<Keyword>calmodulin</Keyword>
</KeywordGroup>
<KeywordGroup Language="En">
<Keyword>PI3K/Akt</Keyword>
</KeywordGroup>
<KeywordGroup Language="En">
<Keyword>ERK1/2</Keyword>
</KeywordGroup>
<biblist>
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</bib-other>
<bib-other>
<bibtext seqNum="2"> Bartolomé F, de las Cuevas N, Muñoz U, Bermejo F, Martín-Requero A: Impaired apoptosis in lymphoblasts from Alzheimer's disease patients: cross-talk of Ca<sup>2+</sup>/calmodulin and ERK1/2 signalling pathways. Cell Mol Life Sci 64:1437-1448, 2007.</bibtext>
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