Obsah souboru
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<JournalTitle>Journal of Applied Biomedicine</JournalTitle>
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<CoverDate Year="2010" Month="12" Day="1"/>
<CoverDisplay>Number 4 / December 2010</CoverDisplay>
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<Article ArticleType="Original">
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<ArticleDOI>10.2478/v10136-009-0021-9</ArticleDOI>
<ArticlePII>1153213U6881W8Q4</ArticlePII>
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<ArticleTitle Language="En">Bacterial toxin-antitoxin systems targeting translation</ArticleTitle>
<ArticleFirstPage>179</ArticleFirstPage>
<ArticleLastPage>188</ArticleLastPage>
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<RegistrationDate>20101116</RegistrationDate>
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<ArticleHeader>
<AuthorGroup>
<Author AffiliationID="A1">
<GivenName>Ramón</GivenName>
<Initials/>
<FamilyName>Díaz-Orejas</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Author AffiliationID="A1">
<GivenName>Elizabeth</GivenName>
<Initials/>
<FamilyName>Diago-Navarro</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Author AffiliationID="A1">
<GivenName>Ana</GivenName>
<Initials>María Hernández</Initials>
<FamilyName>Arriaga</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Author AffiliationID="A1">
<GivenName>Juan</GivenName>
<Initials/>
<FamilyName>López-Villarejo</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Author AffiliationID="A1">
<GivenName>Marc</GivenName>
<Initials/>
<FamilyName>Lemonnier</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Author AffiliationID="A1">
<GivenName>Inma</GivenName>
<Initials/>
<FamilyName>Moreno-Córdoba</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Author AffiliationID="A1">
<GivenName>Concha</GivenName>
<Initials/>
<FamilyName>Nieto</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Author AffiliationID="A1">
<GivenName>Manuel</GivenName>
<Initials/>
<FamilyName>Espinosa</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Affiliation AFFID="A1">
<OrgDivision/>
<OrgName>Departamento de Microbiología Molecular y Biología de las Infecciones, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain</OrgName>
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<Abstract Language="En">Toxin-antitoxin systems (TAS) emerged more than 25 years ago and have since developed as an important field in molecular microbiology. TAS are autoregulated operons coding a stable toxin and an unstable antitoxin found in the plasmids and chromosomes of Bacteria and Archaea. The conditional activation of their toxins interferes with cell growth/viability and, depending on the context, can influence plasmid maintenance, stress management, bacterial persistence, cell differentiation and, it is likely also bacterial virulence. This review summarizes recent results on the <i>parD</i> system of plasmid R1 and on the chromosomal <i>relBE</i> systems found in <i>Escherichia coli</i> and in <i>Streptococcus pneumoniae</i> with a focus on the RNase activity of their toxins, their regulation and their biomedical applications and implications.</Abstract>
<KeywordGroup Language="En">
<Keyword>toxin-antitoxin systems</Keyword>
</KeywordGroup>
<KeywordGroup Language="En">
<Keyword>plasmid maintenance</Keyword>
</KeywordGroup>
<KeywordGroup Language="En">
<Keyword>cell growth regulation</Keyword>
</KeywordGroup>
<KeywordGroup Language="En">
<Keyword>toxin RNases</Keyword>
</KeywordGroup>
<KeywordGroup Language="En">
<Keyword>protein synthesis inhibition</Keyword>
</KeywordGroup>
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