Obsah souboru
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<JournalTitle>Journal of Applied Biomedicine</JournalTitle>
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<CoverDate Year="2011" Month="3" Day="1"/>
<CoverDisplay>Number 1 / March 2011</CoverDisplay>
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<Article ArticleType="Original">
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<ArticleDOI>10.2478/v10136-009-0030-8</ArticleDOI>
<ArticlePII>3MN70T904QLU8H41</ArticlePII>
<ArticleSequenceNumber>2</ArticleSequenceNumber>
<ArticleTitle Language="En">Inhibition of blood and tissue cholinesterases by soman in guinea pigs <i>in vivo</i></ArticleTitle>
<ArticleFirstPage>35</ArticleFirstPage>
<ArticleLastPage>41</ArticleLastPage>
<ArticleHistory>
<RegistrationDate>20101206</RegistrationDate>
<ReceivedDate>20101206</ReceivedDate>
<Accepted>20101206</Accepted>
<OnlineDate>20101206</OnlineDate>
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<ArticleHeader>
<AuthorGroup>
<Author AffiliationID="A1">
<GivenName>Jiří</GivenName>
<Initials/>
<FamilyName>Bajgar</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Author AffiliationID="A1">
<GivenName>Jiří</GivenName>
<Initials/>
<FamilyName>Kassa</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Author AffiliationID="A2">
<GivenName>Miroslav</GivenName>
<Initials/>
<FamilyName>Pohanka</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Author AffiliationID="A1">
<GivenName>Jana</GivenName>
<Initials>Žďárová</Initials>
<FamilyName>Karasová</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Author AffiliationID="A3">
<GivenName>Ladislav</GivenName>
<Initials/>
<FamilyName>Novotný</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Author AffiliationID="A1">
<GivenName>Josef</GivenName>
<Initials/>
<FamilyName>Fusek</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Author AffiliationID="A4">
<GivenName>Václav</GivenName>
<Initials/>
<FamilyName>Bláha</FamilyName>
<Degrees/>
<Roles/>
</Author>
<Affiliation AFFID="A1">
<OrgDivision/>
<OrgName>Department of Toxicology, University of Defence, Hradec Králové, Czech Republic</OrgName>
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</Affiliation>
<Affiliation AFFID="A2">
<OrgDivision/>
<OrgName>Center of Advanced Studies, University of Defence, Hradec Králové, Czech Republic</OrgName>
<OrgAddress/>
</Affiliation>
<Affiliation AFFID="A3">
<OrgDivision/>
<OrgName>Central Vivarium, University of Defence, Hradec Králové, Czech Republic</OrgName>
<OrgAddress/>
</Affiliation>
<Affiliation AFFID="A4">
<OrgDivision/>
<OrgName>Department of Public Health, Faculty of Military Health Sciences, University of Defence, Hradec Králové, Czech Republic</OrgName>
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<Abstract Language="En">Guinea pigs were intoxicated intramuscularly with different doses of soman, and cholinesterase activities were determined in the blood, diaphragm and parts of the brain - the pontomedullar area, the frontal cortex and the basal ganglia. The time course of poisoning following low doses (1,3, 5 μg/kg) and a dose equal to 1xLD<sub>50</sub> (28.5 μg/kg) were studied. The dose having a negligible effect on cholinesterases in the tissues studied was assessed at 1-3 μg/kg, and, following administration of a dose of 5 μg/kg, statistically significant blood cholinesterase inhibition was demonstrated.</Abstract>
<KeywordGroup Language="En">
<Keyword>blood</Keyword>
</KeywordGroup>
<KeywordGroup Language="En">
<Keyword>brain parts</Keyword>
</KeywordGroup>
<KeywordGroup Language="En">
<Keyword>cholinesterases</Keyword>
</KeywordGroup>
<KeywordGroup Language="En">
<Keyword>guinea pig</Keyword>
</KeywordGroup>
<KeywordGroup Language="En">
<Keyword>soman</Keyword>
</KeywordGroup>
<KeywordGroup Language="En">
<Keyword>inhibition <i>in vivo</i></Keyword>
</KeywordGroup>
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